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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '721cf7ba30ceab626d66c0aef7c7e728cb22f16a8c9f34fa92a32d6ac79d6829' 
  AND token = '43U82I5/yavU+2m++eDhnnfMrI22DLqdTPO3LA2aILA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}