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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '253144c1ca9500e1049eab3d6d661687aad7a8e2db27c5393f612118437ceed0' 
  AND token = 'qtd+YRiPRJGSJ+xa9/xWpSL5NtGdOOICa/nEcQ1mzcY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00040

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}