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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78378d39f88e073ac5336e272f65f71374023309faef75b55ef4c30e5d3acb99' 
  AND token = 'ZCw3wKq+j3UBvDfa8NS7UrUM9B8XP4M/OZA1o2bl/8c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00043

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}