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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'adf326f2e03a1f3be77079b8608b5b0a0e742053e65661ad5d4e1302e1222cb5' 
  AND token = 'DJTalJBN6cGuHMe/Xey2pA//3zslTL3ROzwbBIwNI2A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}