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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b4a7e2406a3170a4885019f452e021521bdeae72e0f7374a2ac482544e2f05e6' 
  AND token = 'SuIgFnHUhu8lnJ+HfAV7IusFddRiQMjIJcZ3DoT2Gb4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}