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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '421d613f442921693f755200f6244f12a001e80a11444e19533e4d4f2008a9be' 
  AND token = 'p4uvB9hDHia+UhQkHjHSJco4HhJPZzYoi56L5g5lK9c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}