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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c421e96240ebf4a081959e9287804db2c6a3d0eb3a8255c41fef453c10331402' 
  AND token = 'Xkw1seh9hQs0wFEEd6jINX1VlUtOAwJEZ8nBeHVowjg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}