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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22c6f961ec1941d65389d06155a0e5e1c39697f1e5d962c9138814dd44cbbece' 
  AND token = 'LdL/qdiClMeRnmOtuVNkpAcyr5SlMhcSy/UGEcIuIQc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}