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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a2f59b7ab4430d018cf411338a6c531d9ad2637a63e5878e9eb54136edefcb43' 
  AND token = 'GU2671LP+uN/dwtk5u0IUqyOdA1kIFsmdZPdyZ2aqGY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00058

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}