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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '722c33f927b11534bb308542ebf9e40a7376f50a27926686ebceb0f67e9b3de2' 
  AND token = 'rMZ+LN2A+cgY27RZcPnhOcpnb9qW8x2f7T69/xdRZ1M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}