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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22b887e071f9b22d7d0d34127c26e34d90e6c135386b17bf7aa02ab257d6679b' 
  AND token = '1GIwe4C2gesflvgSg7IltSynCMM2BzfwW9GUgkzDNyg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}