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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '227603a9b8250ea840294746166dcace8813179f0d59b1c8e474cb7eb7add9f3' 
  AND token = '4DAQNIXRyVEhSQmWNCAMW4lAi5YiR/pGAgoqpqj800Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}