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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '14bfa1dfefc9e7baca7b39b61e96e31f0d46e05da9c7c9b105d8d06d40106290' 
  AND token = 'wqu1taGaORL7dv879A+GQCt1BNbENSF895yXTgEeitg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00049

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}