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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b647648ea06098ceccece7a1ba00a482da8fbb9abcd980376e128e5a286609dd' 
  AND token = 'botEtLh/Z/+uFz0BO+iZCBNNQRSKEv2T9tGRwF/EtF0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00056

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}