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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22c977d34b0e6eeafb31ab17020db11b8ba542496159aba1bf6de10c1061a556' 
  AND token = 'YPbzgLIRdyLIPmlFHOQQWJfoeV6nTh1vFIMTxQ0MEM8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}