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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45da2c79c38c9145cb225ef624482001b237f18c1b815827deafbf370944c607' 
  AND token = 'zLRRYpFReMZlybD0P9uPIKDpvXc0IjP6jsHFpLoly/o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}