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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af557b9fe36b3bef15dc91c90a607047009a0c502e91347422b314e338d5fe90' 
  AND token = '1gH8ZZrJ07ZsDNv87vrfPW34tuNCkjpxzEgSmtDF2tU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}