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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3525e4601f35f9eb174188fdfd1ee1ff123b681e8160e0ebf7e44a902e5cc105' 
  AND token = 'A7OUTQ0YKHxLrlrGmaNBwLbTR3+1+Le6aPhVYkPY6k4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}