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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9ccac0f6410ee78a63468a2653450a4e6eca700b8fd497cade86a6348a66baf6' 
  AND token = 'zSbfRe2se8Lqqcnd+hm+mMFMcupqJ1GG8z8ieWzs45U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}