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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '389b6f681b1e16d121f7632391ee44def17c798f1dde6b011bea572cf1eb7361' 
  AND token = 'zz+NX8voQJzfDt1UY3El3Jan4gKnsK4T0l/ZWvEJNco=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}