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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c22b71721e84d3ad4564f4e0e09cdf74d8ced248902e66da9e610db324590d3e' 
  AND token = 'rr6L276cnzeb/c4PcqfZ8GhE2ZVmSQTgTRuT35CGVdg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}