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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6377a57b2d33efeab071e9282410f23ed36a21d1a33c16278b7096f77a3f1e9f' 
  AND token = 'wnPT2sqjBFGgF49YRn9EqrKz8+FtmbHyqPCU0NfPyyU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}