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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50d59c18405e4946838fe539fd1a7bb7569d2cb02969f77baf49b966e0202efb' 
  AND token = 'C7ZsudBKDPnjDPEm2sBQDTOb4dP3c7p2Vi4JEubF9xA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}