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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c1ed46cb38ebca3d781adef426c486836d76a096ed98d4bcc85d42b4401bbb07' 
  AND token = 'HZ2GzNXm0+fhIgaEvie5YHVpbrAtR5S+yrJYBS3tLvc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}