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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b4d99e25a02360fe10c34977ce374bb6e9eb6e7877b3c3bc4f6801198f0b6e50' 
  AND token = 'YQlebnqVd/dvMM35ZmyAss0IeH7wfyKWpXU1DZUTRZw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}