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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9b22f29ce7614bcb8be4600e94db82c854758ae8985f3bb919c88e12df4aca68' 
  AND token = 'qvEVk24MNR6KNZ+kiNEy/CSXWNVSHk6+XwjC5yBvKsc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}