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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e78218cbf4ee29b3f964e527d4a268385f3bfd6217085ee2bf27492f1fec053' 
  AND token = '+N6aFrCFcSO0uUscB5k3Xe5iEgYox/M09PTvDRpmGOc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}